Recommendations:
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Define only variables you need as symbols
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Do not configure publishing Intervals to short (increase load)
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Use different subscriptions with different publishing intervals in order to decrease load
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Do not use sampling intervals faster then publishing intervals as long as AC500 OPC UA server don‘t support Queue Size different from 1
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Be careful: Setting „0“ at sampling Interval at client will be interpreted in server as „as fast as possible“, which is 100ms at AC500 and create a high load.
Publishing and sampling intervals in UaExpert

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Right-Click on an Item in “Data Access View” and click “Subscription Settings”.
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Set the recommended values.
Life Time Count: Number of publishing intervals in which client has to send publish requests to the server. After this period without request from client, subscription in server will be deletet.
Max Keep Alive Count: If there are no new data to send, server can skip a publishing interval. After the alive count, server has to send, even if there are no new data.
Click [OK].
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Right-Click on an Item in “Data Access View” and click “Monitored Item Settings”.
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Set the recommended values.